Genetics at a Glance: NOS-Uncoupling

This is one of the most common questions I get asked regarding detox.  This is also something often overlooked in the functional and natural medicine arena. In order to understand we need to first take a look at where oxidative stress comes from and how our detox system works to remove oxidative stress.  We will also look at the three cycles which work hand in hand: methylation, transsulfuration(detox), and biopterin(neurotransmitters).  Nitric oxide is produced in biopterin pathway and when it gets out of balance or when things in the other pathways are out of balance a cascade of adverse health events take place which put a large strain on our detox pathways and if we try to use those pathways we can create even more stress!  Much like trying to used a toiled which is clogged.